PROBLEM TO BE SOLVED: To provide a method for reducing CD36 expression in a cell.SOLUTION: The present invention provides a method comprising contacting a cell with an effective amount of an aromatic-cationic peptide having at least one net positive charge； a minimum of four amino acids； a maximum of about 20 amino acids； a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) in which 3 pm is the largest number that is less than or equal to r+1； and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) in which 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pmay also be 1.SELECTED DRAWING: None【課題】本発明は、細胞でCD36の発現を減少させる方法を提供する。【解決手段】本発明の方法は、以下の性質を有する芳香族性陽イオンペプチドの有効量と細胞を接触させることを含む：少なくとも1つの正味の陽電荷；最小限4つのアミノ酸；最大限約20のアミノ酸；正味の陽電荷の最小数（pm）とアミノ酸残基総数（r）との間で、3pmがｒ＋１以下の最大の数であるという関係；及び芳香族基の最小数（a）と正味の陽電荷の総数（pt）との間で、2aはpt＋1以下の最大数であるが、aが1のときはptもまた1でありえる関係。【選択図】なし
