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IMPROVED PROCESS FOR PREPARATION OF PHARMACEUTICAL GRADE INSULIN GLARGINE
专利权人:
发明人:
DR SANJEEV KUMAR SHARMA,MR RAMDEV GODARA,MR BALESHWER PRASAD SINNGH
申请号:
IN2153/MUM/2015
公开号:
IN2015MU02153A
申请日:
2015.06.04
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
The present invention relates to the simple and cost effective process for preparation of pharmacopoeial grade Insulin Glargine from a bacterial fermentation process followed by isolation of IBs, refolding, enzymatic conversion and chromatographic purification. Pure Insulin Glargine is lyophilized or crystallized to obtain pharmacopoeial grade Insulin Glargine. The invention also relates to the process of enzymatic conversion of purified Proinsulin Glargine using trypsin in the chromatographic column elute, wherein the ratio of trypsin to purified Proinsulin Glargine is 1:500 to 1:2000.
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中国工程科技知识中心
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