Hillman Jeffrey D.,Smith James Leif,Wilson-Stanford Shawanda R.
申请号：
US201314381420
公开号：
US9963488(B2)
申请日:
2013.02.22
申请国别(地区):
美国
年份:
2018
代理人:
McDonnell Boehnen Hulbert & Berghoff LLP
摘要：
The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of antibiotics wherein the amino acid at position (1) is changed to Ile or Gly, the amino acid at position (4) is changed to an Ala, the amino acid at position (4) is removed, the amino acid at position (5) is changed to an Ala, or wherein, as in the case of MU1140, the amino acid at position (13) is Arg, the Arg at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.
