AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH;AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;LION TCR
发明人:
GUCCIONE, ERNEST,WEE, KENG BOON DAVE,BERTOLETTI, ANTONIO
申请号：
CA3066035
公开号：
CA3066035A1
申请日:
2018.06.27
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to antisense oligonucleotides for modulating thefunction of a T cell, including antisenseoligonucleotides that hybridise to IFN-.gamma., granzyme, perforin 1, PD-1,PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA,CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, thepresent invention relates to antisenseoligonucleotides capable of inducing exon skipping of RNA. Also claimed is amethod for further modifying the specificity of said T-cell byproviding for a T cell receptor gene.
