KOSLEY, JR., RAYMOND W.,高斯雷 瑞蒙,高斯雷 瑞蒙,SHER, ROSY,薛尔 罗西,薛爾 羅西
申请号：
TW099130956
公开号：
TWI495639B
申请日:
2010.09.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention relates to a series of substituted dihydro benzocycloalkyl-oxymethyl oxazolopyrimidinones of formula (I):Wherein n, R1, R2, R3, R4, R5and R6are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, cognition deficit disorders, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.本發明係關於式(I)的一系列取代的二氫苯并環烷基氧甲基唑并嘧啶酮:其中n、R1、R2、R3、R4、R5以及R6如本文所定義。本發明還涉及製備這些化合物的方法,包括新穎中間體。本發明之化合物是代謝型麩胺酸受體(mGluR)調控劑,尤其是mGluR2受體調控劑。因此,本發明之化合物可作為藥劑使用,尤其可用於治療和/或預防各種中樞神經系統疾病(CNS),包括但不限於急性和慢性的神經退化疾病、精神病、認知能力缺陷、痙攣、焦慮症、抑鬱症、偏頭痛、疼痛、睡眠障礙及嘔吐。
