AMIR PESYAN,ペスヤン，アミール,BALANDRIN MANUEL F,バランドリン，マニュエル・エフ,ペスヤン,アミール,バランドリン,マニュエル・エフ
申请号：
JP2015095429
公开号：
JP2015166370A
申请日:
2015.05.08
申请国别(地区):
JP
年份:
2015
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide novel compounds with anticonvulsant activity that exhibit increased/improved toxicological safety, increased/improved metabolic stability, longer half-life, and/or a superior side effect profile, while producing similar or increased biological activity, when compared to currently available central nervous system (CNS) therapeutic agents.SOLUTION: This invention relates to novel amide-based compounds that represent a formula 1. The pharmaceutically active compounds may also show utility in the treatment of central nervous system (CNS) diseases and disorders, such as anxiety, depression, insomnia, migraine headaches, schizophrenia, Parkinson's disease, spasticity, Alzheimer's disease, and bipolar disorder. Furthermore, the compounds may additionally find utility as analgesics (e.g., for the treatment of chronic or neuropathic pain) and as neuroprotective agents useful in the treatment of stroke(s), chronic neurodegenerative diseases (such as Alzheimer's disease and Huntington's disease), and/or traumatic brain and/or spinal cord injuries. Moreover, the compounds may also be useful in the treatment of status epilepticus and/or as chemical countermeasures.【課題】現存する中枢神経系（CNS）治療薬に比べて、同等あるいはより優れた生物学的作用を発揮しながら、毒性学的安全性の増大／改善、代謝安定性の増大／改善、半減期の延長および／または優れた副作用プロファイルと抗痙攣作用を示す新規化合物の提供。【解決手段】図１に代表される新規アミド類化合物。この医薬活性化合物は、不安、抑鬱、不眠、片頭痛、統合失調症、パーキンソン病、痙性、アルツハイマー病や双極性障害等の中枢神経系（CNS）疾患や障害の治療、鎮痛剤（例えば、慢性或いは神経因性頭痛の為の）として、脳卒中、慢性神経変性性疾患（アルツハイマー病及びハンチントン病等）、脳や脊髄の損傷の治療において有用な神経保護薬、更に、癲癇重積状態の治療、そして又は化学的対応策としても有用な可能性がある。【選択図】図１
