Chanhyuk Kim,Travis Young,Yu Cao,Jennifer Ma,Minsoo Kim,Stephanie A. Pinkerton,Peter G. Schultz
申请号：
US15644657
公开号：
US20180104354A1
申请日:
2017.07.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.
