GUNZNER, JANET,SUTHERLIN, DANIEL,STANLEY, MARK,BAO, LIANG,CASTANEDO, GEORGETTE,LALONDE, REBECCA,WANG, SHUMEI,REYNOLDS, MARK,SAVAGE, SCOTT,MALESKY, KIMBERLY,DINA, MICHAEL,KOEHLER, MICHAEL F. T.
申请号：
ES05795325
公开号：
ES2377430T3
申请日:
2005.09.02
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I: ** Formula ** in which A is a ring selected from the group consisting of A1, A2, A3, A4, A5, A6 and A7: ** Formula ** in which Z1 is O, S or NR5, wherein R5 is H or alkyl； Z2 is CH, CR2 'or N； R2 and R2 'is Cl； and n is 1, or A is a ring A1a, A1b, A2a, A3a, A3b, A4a, A5a, A6a, A7a: ** Formula ** X is alkylene, NR4C (O), NR4C (S), N (C ( O) R1) C (O), NR4SO, NR4SO2, NR4C (O) NH, NR4C (S) NH, C (O) NR4, C (S) NR4, NR4PO or NR4PO (OH)； Y is absent, CHR4, O, S, SO, SO2 or NR4, R1 is selected from the group consisting of alkyl, a carbocycle or a heterocycle, each of which is optionally substituted with hydroxyl, halogen, amino, carboxyl, amidino , guanidino, carbonyl, nitro, cyano, acyl, alkyl, haloalkyl, sulfonyl, sulfinyl, alkoxy, aquylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, a carbocycle or a heterocycle； wherein said amino, amidino, alkyl, acyl, sulfonyl, sulfinyl, alkoxy, alkylthio, carbamoyl, acylamino, sulfamoyl, sulfonamide, carbocycle and heterocycle substituent is optionally substituted with halogen, haloakyl, hydroxyl, carboxyl, carbonyl, or an amino, alkyl, alkoxy, acyl, sulfonyl, sulfinyl, phosphinate, carbocycle or heterocycle which is optionally substituted with hydroxyl, carboxyl, carbonyl, amino, halogen, haloalkyl, alkyl, alkoxy, alkylthio, sulfonyl, sulfinyl, acyl, a carbocycle or a heterocycle； R3 is halogen, hydroxyl, carboxyl, alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, a carbocycle or a heterocycle, wherein each alkyl, acyl, alkoxy, alkoxycarbonyl, carbamoyl, alkylsulfide, sulfinyl, sulfonyl, carbocycle and heterocycle is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, sulfonyl or alkoxy； R4 is H or alkyl； m is 0-3； and its salts and solvates.Un compuesto de fórmula I: **Fórmula** en la que A es un anillo seleccionado del grupo que consiste en A1, A2, A3, A4, A5, A6 y A7: **Fórmula** en las que Z1 es O, S o NR5, en el que R5 es H o alquilo； Z2 es CH,
