The present invention relates to pyrazolopyridine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.本發明係關於具有作為TTX-S通道之電壓門控鈉通道的阻斷活性，在治療或預防電壓門控鈉通道參與之失調或疾病時有效的吡唑並吡啶衍生物。本發明還係關於包含該些化合物之藥物組合物及該些化合物和組合物在預防或治療電壓門控鈉通道參與之該種疾病中的用途。
