The present invention relates to pyrrolopyridinone derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.本發明係關於具有作為TTX-S通道之電壓門控鈉通道的阻斷活性且在治療或預防電壓門控鈉通道參與之障礙和疾病中有效的吡咯并吡啶酮衍生物。本發明亦係關於包含該等化合物之醫藥組成物及該等化合物和組成物在預防或治療電壓門控鈉通道參與之前述疾病中之用途。
