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מיקרו-רנ" א 19a/19b לשימוש בטיפול במצב פתולוגי הקשור לאובדן עצם או תפקוד שרירי מופחת
专利权人:
UNIVERSITATSKLINIKUM HAMBURG-EPPENDORF
发明人:
申请号:
IL26968319
公开号:
IL269683D0
申请日:
2019.09.26
申请国别(地区):
IL
年份:
2019
代理人:
摘要:
The invention relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with bone loss, in particular osteoporosis and osteogenesis imperfect (01). The inhibitors are also useful for inducing an anabolic effect in bone, either alone or when administered in combination with parathyroid hormone or a recombinant fragment thereof. The invention further relates to inhibitors of microRNAs 19a and 19b and their use for treating or preventing conditions or diseases which are associated with reduced muscle function, in particular muscle degeneration and muscle atrophy. The inhibitors are also useful for stabilizing and/or strengthening muscle function. In addition, inhibitors of microRNAs 19a and 19b can be used for treating or preventing cancer-related bone destruction or bone metastasis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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