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NOVEL [3,2-C] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF
专利权人:
发明人:
BIJU PURAKKATTLE,BERLIN MICHAEL Y,LIM YEON HEE,BITAR REMA D,MCCORMICK KEVIN D,ASLANIAN ROBERT G,LEE YOON JOO,ZHENG JUNYING,HUANG YING,WON WALTER
申请号:
IN9941/DELNP/2011
公开号:
IN2011DN09941A
申请日:
2011.12.16
申请国别(地区):
IN
年份:
2013
代理人:
摘要:
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas (H-A), (II-A1 ), (II-A2), (II-A2.1 ), (ll-A-2.2), (II-A-2.3), (II-A4), (H-B), (H-C), (III), (IV), (V), (VI), as described herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.
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