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Derivatives of 2 - (3 - pirazolopiridin - il) pyrimidine as jak inhibitors
专利权人:
ALMIRALL; S.A.
发明人:
BERNAT VIDAL JUAN,JACOB GONZALEZ RODRIGUEZ,JOAN TALTAVULL MOLL,CRISTINA ESTEVE TRIAS
申请号:
ARP160101733
公开号:
AR104963A1
申请日:
2016.06.10
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
2 - (pirazopiridin-3-il) pyridine derivatives and their preparation procedures, including the drug synthesis of these derivatives and their use as therapeutic agents for the inhibition of the drug. 1. Claim 1: derived from 2 - (pyridine-3-il) pyridine, used in the treatment of human body or animals, derivative 2 - (pyridine-3-il) pyridine, is a formula compound (1),Or salts, or solutions, or monoxides, or stereoisomers, or pharmaceutically acceptable derivatives, where X represents a group of o-o-nrc -;R¹ and R² are independently selected from the group consisting of a hydrogen atom, a halogen atom, a linear or branched C₁₋₄ alkyl group, a linear or branched C₁₋₄ alkoxy group, and a -CN group; R³ is selected from the group consisting of a hydrogen atom, a linear or branched C₁₋₄ alkyl group, a group - (CH₂) ₁₋₃NRR and a group - (CH₂) ₁₋₃-pyrrolidine; G¹ is selected from the group consisting of a group -CN, a group -CO-Rᵃ,-Group o-r8310a,a group - (CHR⁷) ₘ-NRR, a phenyl group, a monocyclic C₅₋₇ cycloalkyl group, a monocyclic 5- to 6-membered heteroaryl group containing at least one hetero atom selected from O, S, and N and a heterocyclyl group of 5 a 6 monocyclic containing at least one hetero atom selected from O, S, and N, in which the phenyl, cycloalkyl, heteroaryl, and heterocyclyl groups are unsubstituted or substituted with one or more substituents selected from a halogen atom, a hydroxyl group , a linear or branched C₁₋₄ alkyl group, a linear or branched C₁₋₆ hydroxyalkyl group, a linear or branched C₁₋₄ alkoxy group,a group - (CH₂) ₀₋₂NRR, a group - (CH₂) ₀₋₂CN and a group -CO-Rᵃ,wherein Rᵃ represents a hydrogen atom, a hydroxyl group, a linear or branched C₁₋₃ alkyl group, a linear or branched C₁₋₃ alkoxy group, or an amino group; Q is selected from the group consisting of the compounds of the group of formulas (2) in which R⁴ is selected from the group consisting of a linear or branched C₁₋₄ alkyl group, a -CO-R group, a -CO group ( CH₂) ₁₋₂-OH; a group -CO
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