ЧОБАНИАН Гарри (US),ЛИН Линус С. (US),ЛЮ Пин (US),ЧИОДА Марк Д. (US),ДЕВИТА Роберт Дж. (US),НАРГУНД Рави П. (US),ГО Янь (US),ХАМИЛЛ Теренс (US),ЛИ Вэньпин (US),ХЕНДЗЕ Даррел А. (US)
申请号：
RU2012136624/15
公开号：
RU2012136624A
申请日:
2011.01.25
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition comprising: an FAAH inhibiting compound of formula I: or a pharmaceutically acceptable salt thereof, wherein X is S or SO； n is 0, 1 or 2； R is selected from the group consisting of: (1) aryl and (2) HET wherein R is optionally mono- or disubstituted with R and R； and where R and R are independently selected from the group consisting of: (a) halogen, (b) -CN, (c) mono-, di- or trihaloalkyl, (d) mono-, di- or trihaloalkyl, (d) -OCalkyl, optionally substituted with hydroxyl, halogen or amino, (e) -Calkyl, optionally substituted with one or two substituents selected from hydroxyl, CN, -CHF and -CF, (f) -Calkyl-Cycloalkyl, optionally substituted with hydroxy, halogen or CN, (g ) -S (O) C1-6alkyl, (h) -S (O) NRR, (i) -C (O) -NH-NRR, (j) -C (O) -OH, (k) -C (O) OC alkyl optionally substituted with halogen or hydroxy, (l) -C (O) -NRR, (m) -C (O) -C alkyl, optionally mono-, di- or triz substituted by halogen, (o) -C (NR) -NRR, (p) NO, (q) aryl, (r) -C (O) -NH-NH-C (O) H, (s) -CH-C (O) -O-C1-6 alkyl, where CH may be optionally substituted with C1-6alkyl or OH, (t) -CH-C (O) NRR, where CH may be optionally substituted with C1-6alkyl or OH, and (u) -NRR, where each p) and (q) are mono- or disubstituted substituents selected from: (1) halogen, (2) CN, (3) OH, (4) -Calkyl optionally substituted with hydroxy, halogen or cyano, (5) -CF , (6) -OCalkyl optionally substituted with hydroxyl or halogen, (7) -C (O) OH and (8) -C (O) O-Calkyl； (9) -C (O) -NRR, (10) - NH, (11) oxo, (12) = S, provided that the substituent ora (q) is different from oxo or = S, where each of R, R, R, R, R, R, R, R, R, R, R, R, R, R and R are independently selected from H and C1-6 alkyl, or R and R or R or R or R or R and R or R and R or R and R or R and R are connected together with the nitrogen atom to which they are connected to form a ring and form a 5-membered heterocyclic1. Фармацевтическая композиция, содержащая:ингибирующее FAAH соединение формулы I:или его фармацевтичес
