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New phenylpyrrole derivatives
专利权人:
第一三共株式会社
发明人:
古川 詔大,福崎 剛広,大西 由香利,小林 英樹,松藤 哲義,本田 雄,松井 由美,小西 正博,上田 健二郎
申请号:
JP2010053934
公开号:
JP5074545B2
申请日:
2010.03.11
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R 1 represents, for example, a C 1 -C 6 alkyl group, a C 1 -C 6 alkoxy group or a C 1 -C 6 halogenated alkyl group, A and R 1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group ±, R 2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group ± or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group ±, R 3 represents a hydroxy group or a C 1 -C 6 alkoxy group, and Substituent Group ± consists of, for example, a halogen atom, a C 1 -C 6 alkyl group, a C 1 -C 6 alkyl group substituted with 1 or 2 hydroxy group(s), a C 1 -C 6 alkylsulfonyl group, and a group represented by the formula -V-NR 5 R 6 (wherein, V represents a carbonyl group or a sulfonyl group, and R 5 and R 6 may be the same or different and respectively represent a hydrogen atom or a C 1 -C 6 alkyl group, or R 5 and R 6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C 1 -C 6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].
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