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9-SUBSTITUTED-8-OXOADENINE COMPOUND
专利权人:
DAINIPPON SUMITOMO PHARMA CO.; LTD.
发明人:
KURIMOTO, AYUMU,栗木步,栗木步,HASHIMOTO, KAZUKI,桥本和树,橋本和樹,ISOBE, YOSHIAKI,矶部义明,磯部義明,BROUGH, STEPHEN,史帝芬 布洛,史帝芬 布洛,MILLICHIP, IAN,艾恩 米里契,艾恩 米里契,WADA, HIROKI,和田博喜,和田博喜,BONNERT, ROGER,罗杰 伯能特,羅傑 伯能特,MCINALLY, T
申请号:
TW094109180
公开号:
TWI392678B
申请日:
2005.03.24
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
The bright Ti Gong mono- Seed of this Hair have Mian Yi Tone Festival activity (Zhu such as Gan Interference Su Lure Guide activity) and antiviral Elixirs can be acted effectively as Ji being subjected to Which on the 8- oxygroups adenine compound of the quick property Elixirs of Kang Over or its Drug Li Learn, The compounds are represented by following formula (1):Qi Zhong Ring A of [represent 6-10 STAFF Fang Zu Tan Ring and its Class like object, R Dai Biao Halogen elements atom, alkyl and its Class are like object, n represents the whole Number of 0-2, alkyl is stretched in Z1 representatives, X2 represents oxygen atom, sulphur atom, SO2, NR5, CO, CONR5, NR5CO and its Class like object, Y1, Y2 and Y3 Independence are vertical to be represented Single Key or stretches alkyl, X1 represents oxygen atom, sulphur atom, NR4 (R4 Department Hydrogen atoms or alkyl) Huo Single Key, R2 represents the alkyl of The substitutions or non-The substitutions, and R1 represents Hydrogen Yuan, Hydroxyalkyl bases, alkoxy, alkoxy carbonyl Huo Halogen bases alkyl].本發明提供一種具有免疫調節活性(諸如干擾素誘導活性)且能有效用作抗病毒劑及抗過敏性劑之8-氧基腺嘌呤化合物或其藥理學上可接受之鹽,該化合物由下式(1)代表:[其中環A代表6-10員芳族碳環及其類似物,R代表鹵素原子、烷基及其類似物,n代表0-2之整數,Z1代表伸烷基,X2代表氧原子、硫原子、SO2、NR5、CO、CONR5、NR5CO及其類似物,Y1、Y2及Y3獨立代表單鍵或伸烷基,X1代表氧原子、硫原子、NR4(R4係氫原子或烷基)或單鍵,R2代表經取代或未經取代之烷基,R1代表氫原子、羥基、烷氧基、烷氧基羰基或鹵基烷基]。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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