SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR NEUROMELANIN-SENSITIVE MAGNETIC RESONANCE IMAGING AS A NON-INVASIVE PROXY MEASURE OF DOPAMINE FUNCTION IN THE HUMAN BRAIN

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专利权人:

THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人:

HERNANDEZ, GUILLERMO HORGA,CASSIDY, CLIFFORD MILLS

申请号：

CA3122391

公开号：

CA3122391A1

申请日:

2019.10.10

申请国别(地区):

CA

年份:

2020

代理人:

摘要：

[00144] An exemplary system, method and computer-accessible medium for determining a dopamine function of a patient(s) can include, for example, receiving imaging information of a brain of the patient(s), determining a Neuromelanin (NM) concentration of the patient(s) based on the imaging information, and determining the dopamine function based on the NM concentration. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s). The topographical pattern(s) can include a pattern(s) of cell loss in the SN. The NM concentration can be based on a NM loss in the brain of the patient(s).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/