This invention relates to a kind of oral probiotic crystal ball structure with acid resistance and slow-release, which mainly includes a core containing probiotics, a protective layer outside the core, an anti bile salt layer coated outside the protective layer, a slow-release layer coated outside the anti bile salt layer, an acid resistant layer coated outside the slow-release layer, and an isolation layer coated outside the acid resistant layer.Therefore, the multilayer coating structure is used to create a barrier between the core and the external environment, effectively protect the probiotics contained in the core, so as to reduce the influence of temperature, pH value, moisture, oxidation or other substances, and improve the storage stability of the invention. In addition, the multi-layer coating control can make the probiotics release slowly in the digestive tract and avoid suffering from stomach acid and gall In the case of salt damage and inactivation, the survival ratio and availability of probiotics in the intestinal tract can be improved.本創作有關於一種抗酸緩釋之口服益生菌晶球結構，係主要包括一含益生菌之核芯、包覆於該核芯外之一保護層、包覆於該保護層外之一抗膽鹽層、包覆於該抗膽鹽層外之一緩釋層、包覆於該緩釋層外之一抗酸層、以及包覆於該抗酸層外之一隔離層。藉此，利用該多層包覆結構以產生核芯與外界環境區隔的屏障，有效保護核芯所含益生菌，以降低溫度、酸鹼值、水分、氧化或其它物質等影響，而提高本創作儲存的安定性，另藉由多層物質的包覆控制，以使益生菌可於消化道緩慢控制釋放，並避免遭受胃酸、膽鹽等破壞而失活情形，達到提高益生菌於腸道之存活比例與可利用性等效益。
