INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL; EXECUTIVE YUAN
发明人:
WANG, MEI HUI,王美惠,王美惠,YU, HUNG MAN,于鸿文,于鴻文,KUO, JIA WEI,郭家伟,郭家偉,CHIEN, CHUAN YI,简传益,簡傳益,WANG, PING YEN,王屏燕,王屏燕,WANG, JEN TSUNG,王仁聪,王仁聰,LIN, WUU JYH,林武智,林武智
申请号：
TW102139109
公开号：
TW201425340A
申请日:
2013.10.29
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
A novel gall bladder image agent which comprises a radio-labelled MAG3-tri-galactosamine, and its preparation method, which comprises reacting mercaptoacetyltriglycine (MAG3)-tri-galactosamine, SnF2 and Tc-99m in the presence of phosphate buffer solution (at pH of from 10.0~12.0) to obtain Tc-99m-MAG3-tri- galactosamine, when the MAG3-tri- galactosamine is MAG3-DCM-Lys(Gah-GalNAc)3 (wherein DCM represents dicarboxymethyl group, Gah represents glycine- aminohexyl group), it obtains a labelling yield of at least 90%, and its specific radioactivity is at least 7.0×109 Nq/mg.一種新穎之膽道造影劑及其製造方法,該膽道影劑包括經放射標記之MAG3-三聚半乳糖胺,且該方法係以巰基乙醯基三甘胺酸(MAG3)-三聚半乳糖胺、SnF2在磷酸緩衝液(pH 10.0~12.0)存在下與Tc-99m反應而獲得Tc-99m-MAG3-三聚半乳糖胺,其中當該MAG3-三聚半乳糖胺為MAG3-DCM-Lys(Gah-GalNAc)3(式中DCM表示二羧基甲基,Gah表示甘胺醯基-胺基己基)時,可得至少90%的標記產率,放射比活度至少為7.0×109Bq/mg。
