Yao, Yihong,Carlesso, Gianluca,Coyle, Anthony,Jallal, Bahija,Bowen, Michael
申请号：
AU2008247382
公开号：
AU2008247382B2
申请日:
2008.05.07
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides anti-human ICOS antibodies with increased effectorfunction. The invention further relates to pharmaceutical compositions, immunotherapeuticcompositions, and methods using therapeutic antibodies that bind to the humanICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis(opsonisation) for the treatment and prevention of T cell-mediated diseasesand disorders, such as, but not limited to, chronic infection, autoimmune diseaseor disorder, inflammatory disease or disorder, graft-versus-host disease(GVHD), transplant rejection, and T cell proliferative disorder.
