The present invention provides chimeric and humanization anti-CD19 mouse monoclonal antibody. The invention further relates to use in conjunction with people CD19 antigen and pharmaceutical composition, immunotherapeutic composition and the method for the treatment of antibody that ADCC, CDC and/or carving may be mediated to die, they can treat B cell disease and imbalance with what, such as but unlimited what B cell malignant tumour, autoimmunity disease is treated and prevented, treats and prevents the graft versus host disease(GVH disease) (GVHD) of human graft recipient, body fluid repels and transplanting Hou lymphoproliferative disease.本發明提供嵌合和人源化的抗CD19小鼠單克隆抗體。本發明還涉及使用結合人CD19抗原並可能介導ADCC、CDC和/或雕亡的治療抗體的藥物組合物、免疫治療組合物和方法，它們可用於治療B細胞疾病和失調，例如但不限於B細胞惡性腫瘤，治療和預防自身免疫病，治療和預防人類移植物接受者的移植物抗宿主病(GVHD)、體液排斥和移植後淋巴增殖性疾病。
