The invention relates to methods, uses, and compositions (e.g., articles of manufacture and kits) for the treatment of diseases associated with IL-22 (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC (e.g., moderate to severe UC)) and Crohn’s disease (CD)) and graft versus host disease (GVHD) (e.g., acute or chronic GVHD)).本發明係關於用於治療與IL-22相關之疾病(例如,發炎性腸病(IBD)(例如,潰瘍性結腸炎(UC (例如,中度至重度UC))及克羅恩氏病(Crohn’s disease,CD))及移植物抗宿主病(GVHD)(例如,急性或慢性GVHD))之方法、用途及組合物(例如,製品及套組)。