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Prevention and treatment of graft-versus-host-disease with defensins
专利权人:
Defensin Therapeutics ApS
发明人:
NORDKILD, Peter
申请号:
AU2018371948
公开号:
AU2018371948A1
申请日:
2018.11.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present invention relates to methods for treatment and/or prevention of acute as well as chronic graft-versus-host-disease (GVHD), and in particular to methods for decreasing mortality and increasing especially long term survival; acute complications associated with GVHD such as diarrhoea, weight loss and sepsis based on normalization of gut, liver, lung and skin microbiota and mucosal defense; rebalance of the immune system with normalization of cytokine production of IFN-γ, TNF-α, 11-4, IL- 5, IL-6, IL-8, IL-9, IL-10 and IL-13 and prevention and/or treatment of cytokine storm; chronic complications associated with GVHD such as bronchiolitis obliterans and scleroderma, the method comprising oral, subcutaneous, intrapulmonary and/or dermal/transdermal administration of one or more mammalian defensins selected from the group of α- and β-defensins in a patient that has or is about to receive an allogeneic hematopoietic stem cell transplantation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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