Luis RODRIGUEZ-BORLADO,Houman HEMMATI,Kiel A. PECK,Linda MARBAN,Jennifer J. MOSELEY
申请号：
US16610859
公开号：
US20200054686A1
申请日:
2018.05.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a method of treating acute or chronic systemic graft-versus-host disease (GVHD) with extracellular vesicles, e.g., exosomes obtained from human cardiospheres or cardiosphere-derived cells (CDCs), wherein systemic GVHD involves, e.g., at least two organs selected from the group consisting of the skin, mucosa, gastrointestinal tract, liver, lungs, joints and fascia, genitalia, and eyes. The present invention also provides a pharmaceutical formulation comprising extracellular vesicles, e.g., exosomes obtained from human cardiospheres or CDCs, for systemic administration, e.g., intravenous infusion, to a human subject in need of treatment of systemic GVHD.
