There is provided herein composition and method for treating autoimmunity and isoimmunization disease or the patients condition, the disease or the patients condition include rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease (IBD) (for example, Crohn disease, ulcerative colitis), optic neuritis, neuromyelitis optica, Sjogren syndrome, psoriasis, systemic scleroderma, ankylosing spondylitis, oneself immunity hepatitis, graft versus host disease(GVH disease) (GvHD) and organ-graft refection.The composition that can be used to treat autoimmune disease includes pyrrolo-pyrazole pkc inhibitor.
