PROBLEM TO BE SOLVED: To provide a proteasome activation accelerator or a senescence- delaying or improving medicine, quasi drug, cosmetic and food that characteristically include a solvent extract from Ganoderma lucidum (a shelf fungus), a kind of polypore. SOLUTION: This invention relates to a proteasome activation accelerator or a senescence-delaying or improving medicine, quasi drug, cosmetic and food that characteristically includes an extract of Ganoderma lucidum (a shelf fungus) with a solvent. The extract of the fungus with a solvent according to this invention has been found to have the proteasome activity-accelerating action.
