PROBLEM TO BE SOLVED: To provide food products and pharmaceuticals effective as compositions which contain extracts of Ebenaceae Diospyros leaves as an active ingredient, have the effect to inhibit the production of secretory protease, and also show the effect to improve osteoarthritis.SOLUTION: The inventors have found that extracts of Ebenaceae Diospyros leaves have matrix metalloprotease inhibitory activity and aggrecanase inhibition, and also have chondrocyte antiinflammation activity in order to complete the present invention.COPYRIGHT: (C)2015,JPO&INPIT【課題】カキノキ科カキノキ属の葉の抽出物を有効成分として含有し、分泌型プロテアーゼの産生抑制効果を示し、さらに、変形性関節症の改善効果を示す組成物として有効な食品や医薬品を提供すること。【解決手段】カキノキ科カキノキ属の葉の抽出物にマトリックスメタロプロテアーゼ阻害活性およびアグリカナーゼ阻害があること、さらには軟骨細胞の抗炎症活性があることを見出し、本発明を完成するに至った。
