PROBLEM TO BE SOLVED: To provide food products and pharmaceuticals effective as compositions which contain extracts of leaves of Laurus, Lauraceae as an active ingredient, have the effect to inhibit the production of secretory protease, and also show the effect to improve osteoarthritis.SOLUTION: The inventors have found that extracts of leaves of Laurus, Lauraceae have matrix metalloprotease inhibitory activity and aggrecanase inhibitory activity, and also have chondrocyte anti-inflammation activity in order to complete the present invention.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】クスノキ科ゲッケイジュ属の葉の抽出物を有効成分として含有し、分泌型プロテアーゼの産生抑制効果を示し、さらに、変形性関節症の改善効果を示す組成物として有効な食品や医薬品を提供すること。【解決手段】クスノキ科ゲッケイジュ属の葉の抽出物にマトリックスメタロプロテアーゼ阻害活性およびアグリカナーゼ阻害があること、さらには軟骨細胞の抗炎症活性があることを見出し、本発明を完成するに至った。【選択図】なし
