Levey Allan I,Peng Junmin,Lah James,Bai Bing,Hales Chadwick McKinley,Chen Ping-Chung,Seyfried Nicholas Thomas
申请号：
US201414199456
公开号：
US9758809(B2)
申请日:
2014.03.06
申请国别(地区):
美国
年份:
2017
代理人:
Emory Patent Group
摘要：
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In certain embodiments, the disclosure contemplates the diagnosis of preclinical or symptomatic stages of Alzheimer's disease, mild cognitive impairment, or chronic traumatic encephalopathy by identification of components of U1 small nuclear ribonucleoproteins or fragments thereof which are capable of forming cytoplasmic tangle-like structures.
