Provide therapeutic combination and/or preparation, comprising: the protein matrix of at least one crosslinking, wherein the protein matrix of at least one crosslinking includes at least one residue of protein and at least one contains saccharide residue and its production method. The interleukin matrix can be by crosslinking overall length or substantially full length protein, such as tropoelastin, elastin laminin, albumin, collagen, collagen monomer, immunoglobulin, insulin, and/or derivative or combinations thereof, contain crosslinking agent with sugar, crosslinking agent derives from such as polysaccharide, such as hyaluronic acid or cellulose derivative. Therapeutic combination with local application or can pass through injection. The disclosure also provides the disclosed composition of system, method and/or kit preparation and/or preparation.
