The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.本発明は、皮膚の健康な老化の促進、皮膚障害の治療、心血管系障害の治療、腎障害の治療、血管形成障害（例えば、癌）の治療、組織障害（例えば、心臓以外の組織障害）の治療、進行性心筋梗塞の治療およびその他の種々の障害（例えば、糖尿病に起因する合併症）の治療のための、新規な化合物およびその医薬組成物、ならびに本発明の化合物および組成物を用いた方法に関する。その他の障害には、限定するものではないが、アテローム性動脈硬化症、冠動脈疾患、糖尿病性腎症、糖尿病性神経障害、糖尿病性網膜症、皮膚感染症、末梢血管疾患、脳卒中等が挙げられる。
