The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and compounds and compositions of the present invention for promoting healthy skin aging, treating skin disorders, treating cardiovascular disorders, treating renal disorders, cancer and the like. Treatment of angiogenic disorders of the body, treatment of tissue damage such as non-cardiac tissue damage, treatment of progressive myocardial infarction, treatment of ischemic injury, and treatment of various other disorders such as complications resulting from diabetes On the way. Other disorders include atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, skin infections, peripheral vascular disease, stroke, asthma, etc. But not limited thereto.本開示は、新規の化合物およびその薬学的組成物、ならびに本発明の化合物および組成物による、皮膚の健康なエイジングの促進、皮膚障害の処置、心血管障害の処置、腎障害の処置、癌などの血管新生障害の処置、非心臓組織損傷などの組織損傷の処置、進行性心筋梗塞の処置、虚血傷害の処置、および糖尿病に起因する合併症などの様々な他の障害の処置のための方法に関する。他の障害としては、アテローム性動脈硬化症、冠動脈疾患、糖尿病性腎症、糖尿病性神経障害、糖尿病性網膜症、糖尿病性心筋症、皮膚の感染症、末梢血管疾患、脳卒中、喘息などが挙げられ得るが、これらに限定されない。
