The present invention relates to novel compounds and pharmaceutical compositions thereof, as well as the promotion of healthy skin aging, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, cancer and the like by the compounds and compositions of the present invention. It relates to a method for the treatment of angiogenic disorders, the treatment of tissue damage such as non-cardiac tissue damage, the treatment of progressive myocardial infarction, and various other disorders such as diabetes-related complications. Other disorders may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infection, peripheral vascular disease, stroke, etc. Not.本発明は、新規の化合物およびその薬学的組成物、ならびに本発明の化合物および組成物による皮膚の健康な老化の促進、皮膚障害の治療、心臓血管障害の治療、腎障害の治療、癌等の血管新生障害の治療、非心臓組織損傷等の組織損傷の治療、進行性心筋梗塞の治療、および糖尿病に起因する合併症等の様々な他の障害の治療のための方法に関する。他の障害には、アテローム性動脈硬化症、冠動脈疾患、糖尿病性腎症、糖尿病性神経障害、糖尿病性網膜症、皮膚の感染症、末梢血管疾患、脳卒中等が含まれ得るが、これらに限定されない。
