BERLANGA ACOSTA, JORGE,GUILLEN NIETO, GERARDO ENRIQUE,GARCIA DEL BARCO HERRERA, DIANA,FERNANDEZ MASSO, JULIO RAUL,ESTRADA GARCIA, MARIO PABLO,GUILLEN PEREZ, ISABEL,SUAREZ ALBA, JOSE,MARTINEZ RODRIGUEZ
申请号：
CA2789161
公开号：
CA2789161C
申请日:
2001.12.17
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
This invention relates to human medicine, and particularly to a pharmaceutical composition comprising Epidermal Growth Factor (EGF) and a Growth Hormone secretagogue hexapeptide (GHRP-6)； being useful to prevent tissue damages due to blood flow suppression and to enhance tissue repair following ischaemic damage. Alternatively, a subject may also receive both EGF and GHRP-6 separately but within a single therapeutic regime to enhance cellular survival when organs are subjected to blood flow deprivation for a critical period of time. This composition attenuates reactive oxygen species (ROS) formation and its associated cytotoxicity. It is useful to promote cellular survival when tissues or organs are exposed to prolonged ischaemic periods. The composition may be used as a prophylactic agent in those subjects prone to multiple organ failure (MOF) such as burn victims, multiple trauma patients, hypoxic neonates, patients with acute respiratory distress syndrome, and necrotizing enterocolitis patients.
