BERLANGA ACOSTA, JORGE,GUILLEN NIETO, GERARDO ENRIQUE,GARCIA DEL BARCO HERRERA, DIANA,FERNANDEZ MASSO, JULIO RAUL,ESTRADA GARCIA, MARIO PABLO,GUILLEN PEREZ, ISABEL,SUAREZ ALBA, JOSE,MARTINEZ RODRIGUEZ
申请号：
CA2398983
公开号：
CA2398983C
申请日:
2001.12.17
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
This invention relates to human medicine, and particularly to a pharmaceuticalcomposition comprising Epidermal Growth Factor (EGF) and a Growth Hormonesecretagogue hexapeptide (GHRP-6)； being useful to prevent tissue damagesdue to blood flow suppression and to enhance tissue repair following ischaemicdamage. Alternatively, a subject may also receive both EGF and GHRP-6separately but within a single therapeutic regime to enhance cellular survivalwhen organs are subjected to blood flow deprivation for a critical period oftime.This composition attenuates reactive oxygen species (ROS) formation and itsassociated cytotoxicity. It is useful to promote cellular survival whentissues ororgans are exposed to prolonged ischaemic periods. The composition may beused as a prophylactic agent in those subjects prone to multiple organ failure(MOF) such as burn victims, multiple trauma patients, hypoxic neonates,patientswith acute respiratory distress syndrome, and necrotizing enterocolitispatients.
