The present invention relates to pharmaceutical active heterocyclic compound and its pharmaceutically acceptable salt and hydrate and include the classification of their compositions. The present invention also relates to the methods for treating or preventing disease or obstacle with what, which comprises application treats or prevents a effective amount of compound as described herein.本發明涉及藥學活性雜環化合物及其藥學上可接受的鹽和水合物、以及包含它們的組合物的類別。本發明也涉及用於治療或預防疾病或障礙的方法,所述方法包括:施用治療或預防有效量的本文所述的化合物。