As protein kinase B inhibitor pyrrolo- [2,3-D] pyrimidine derivatives农业专利-农业学术服务平台

发明人:: P．D．约翰逊,P．D．約翰遜,A．利奇,R．W．A．卢克,R．W．A．盧克,Z．S．马图西亚克,Z．S．馬圖西亞克,J．J．莫里斯,P.D.约翰逊,P.D.約翰遜,A.利奇,R.W.A.卢克,R.W.A.盧克,Z.S.马图西亚克,Z.S.馬圖西亞克,J.J.莫里斯

摘要：: The present invention relates to new formula (I) compound or its salts: wherein Y,Z1,Z2,R1,R4,R5 and n as used in the description,Its available what treats or prevents the disease or medical conditions such as cancer mediated by protein kinase B (PKB). Pass through the method for the PKB diseases mediated and the method for preparing formula (I) compound the invention further relates to the pharmaceutical composition comprising such compound, using this compounds for treating.本發明涉及新的式(I)化合物或其鹽：其中Y,Z1,Z2,R1,R4,R5和n如說明書所述,其可用於治療或預防通過蛋白激酶B(PKB)介導的疾病或醫學病情例如癌症。本發明還涉及包含此類化合物的藥物組合物、使用此類化合物治療通過PKB介導的疾病的方法、以及製備式(I)化合物的方法。