The present invention describes new heteroaryl butanoic acid derivative, is good drug candidates, is good drug candidates especially in terms of leukotriene A 4 hydrolase (LTA4H). The invention further relates to the pharmaceutical compositions comprising the new heteroaryl butanoic acid derivative, the method treated the method for various diseases and obstacle using the compound and prepare the noval chemical compound.本發明描述了新的雜芳基丁酸衍生物,其是良好的藥物候選物,尤其是在白三烯A4水解酶(LTA4H)方面是良好的藥物候選物。本發明還涉及包含所述新的雜芳基丁酸衍生物的藥物組合物、使用所述化合物治療各種疾病和障礙的方法以及製備所述新化合物的方法。