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ГЕМОСТАТИЧЕСКИЙ АГЕНТ, СПОСОБ ОСТАНОВКИ КРОВОТЕЧЕНИЯ И НАЗАЛЬНЫЙ СПРЕЙ
专利权人:
АГРАТЕК ИНТЕРНЕШНЛ, ИНК.
发明人:
БЕРМАН Дин А.,БРИСТОУ Джозеф Ф.
申请号:
RU2014128291
公开号:
RU2014128291A
申请日:
2012.12.12
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The hemostatic agent, which is a reverse micelles based on hydrophobically modified chitosan ( "HMC"), comprising a polymeric chitosan molecules having attached thereto biocompatible hydrophobic moieties in an amount that is sufficient to convert the chitosan molecules in reverse micelles based NMS, with this hydrophobic micelles have an outer portion formed with hydrophobic moieties and a hydrophilic inner portion consisting of positively infected hitozana.2 fragments. The hemostatic agent according to Claim. 1, where the hydrophobic moieties are selected from the class consisting of alkanes and aminokislot.3. The hemostatic agent according to Claim. 1, where the hydrophobic moieties are attached to one end of the respective polymeric chitosan molecules, and the other ends of the molecules are positively charged fragments hitozana.4. The hemostatic agent according to Claim. 1, which is in a physical form selected from the group consisting of foams, gels, sprays, fine solids and liquid suspenziy.5. Method hemostasis in humans or animals, comprising delivering to the site of bleeding or to the area near the site of reverse micelles bleeding based on hydrophobically modified chitosan ( "NMS"), the reverse micelles based NMS contain molecules of the polymer chitosan having attached thereto hydrophobic biocompatible moieties in an amount that is sufficient to convert the chitosan molecules in reverse micelles based on the NMS, wherein the micelles have a hydrophobic outer portion formed hydrophobic fragments, and a hydrophilic inner part consisting of a positively infected1. Гемостатический агент, представляющий собой обратные мицеллы на основе гидрофобно модифицированного хитозана ("HMC"), содержащие молекулы полимерного хитозана, имеющие присоединенные к ним гидрофобные биосовместимые фрагменты в количестве, которое является достаточным для превращения молекул хитозана в обратные мицеллы на основе НМС, при этом мицеллы имеют гидрофобную наружную часть, образованную
来源网站:
中国工程科技知识中心
来源网址:
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