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A HOT MELT FRAGMENTATION PROCESS FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION
专利权人:
STEER ENGINEERING PRIVATE LIMITED
发明人:
PADMANABHAN, BABU,PRODDUTURI, SUNEELA,SEN, HIMADRI
申请号:
IN2295CH2013
公开号:
IN2295CH2013A
申请日:
2013.05.27
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder. Fig. 1 A co-rotating twin screw extruder for forming fragments is disclosed. The extruder comprises of an intake zone for receiving one or more excipient(s) suitable for oral dosage or one or more excipient(s) suitable for oral dosage along with one or more active pharmaceutical ingredient, a melt zone for softening at least one excipient to form a viscous mass or melt and a fragmenting zone for fragmenting and cooling the viscous mass into cooled fragments and an extruder outlet for recovering the cooled fragments from the extruder. Fig. 1
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