COMPOSES DE 2-OXOTHIATOLE AYANT UNE ACTIVITE EN TANT QU'INHIBITEURS DE CPLA2 POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET DE TROUBLES HYPERPROLIFERATIFS
A compound of formula (I') wherein R6 is H, C1-6alkyl, -(CH2)pCOOH, -(CH2)pCOOC1-6alkyl, - (CH2)pCONH2, -(CH2)pCONHC1-6alkyl, -(CH2)pCON(C1-6alkyl)2, R7 is as defined for R6； or and R7 taken together with the atoms joining them can form a 6-membered aromatic or non aromatic, saturated or unsaturated, carbocyclic or heteroatom containing (e.g. O, N or S containing) ring optionally substituted by up to 4 groups R8； each R8 is defined as for R6 or is oxo； R10 is C1-6 alkyl Ar is a C6-14 aryl group, wherein the aryl group may be optionally substituted (preferably in the meta or para position relative to O) with one or more R9 groups； each R9 is halo, OH, CN, nitro, NH2, NHC1-6alkyl, N(C1-6alkyl)2, haloC1-6alkyl, C6-10 aryl group, C7-12 arylalkyl, a C1-10alkyl group, C2-10-mono or multiply unsaturated alkenyl group, OC1-10alkyl group, SC1-10alkyl group -OC1-10alkyl-O-C10alkyl, -C1-10alkyl-O-C1-10alkyl, -OC2-10-mono or multiply unsaturated alkenyl group, OAr2, O(CH2)qAr2, SAr2 or S(CH2)qAr2； wherein Ar2 is phenyl, optionally substituted with one or more of halo, trihalomethyl, C1-10-alkoxy, or C1-10 alkyl； each q is 1 to 3, preferably 1； each p is 0 to 3； or a salt, ester, solvate, N-oxide, or prodrug thereof.
