The present invention provides an extract of Erodium stephanianum Willd, which is capable of suppressing tumor necrosis factor TNF. The present invention further provides an antagonist of the tumor necrosis factor TNF, which includes the aforementioned extract of Erodium stephanianum Willd. The antagonist can be prepared as powders, capsules, pills, liquids, syrups, solutions, suspensions, emulsions, ointments, creams, lotions or patch Also, the extract of Erodium stephanianum Willd can be prepared into powders, capsules, pills, liquids, syrups, solutions, suspensions, emulsions, ointments, creams, lotions or patch, and utilized as medicine by oral, intravenous, parenteral or percutaneous dosing.本發明提供一種老鸛草(Erodium stephanianum Willd.)萃取液,其能抑制腫瘤壞死因子TNFα。本發明亦提供一種腫瘤壞死因子TNFα拮抗劑,其包含前述之老鸛草萃取液。
