MOFFAT, DAVID FESTUS CHARLES,PATEL, SANJAY RATILAL,DAVIES, STEPHEN JOHN,BAKER, KENNETH WILLIAM JOHN,PHILPS, OLIVER JAMES
申请号：
AT07824247
公开号：
AT542820T
申请日:
2007.10.19
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Compound of formula (I) are inhibitors of Polo-like kinases (PLKs), and are useful in treatment of cell proliferative diseases: wherein R1 and R2 are hydrogen, or an optionally substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl group； R3 and R3&prime； are independently selected from hydrogen, &mdash；CN, hydroxyl, halogen, optionally substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl, &mdash；NR5R6 or C1-C4 alkoxy, wherein R5 and R6 are independently hydrogen or optionally substituted (C1-C6)alkyl； ring A is an optionally substituted mono- or bi-cyclic carbocyclic or heterocyclic ring or a ring system having up to 12 ring atoms； T is a radical of formula R-L1-Y1&mdash； wherein R is an alpha amino acid or alpha amino acid ester motif, linked to ring A by linker R-L1-Y1&mdash； as defined in the claims.
