Use of allogenic or syngenic major histocompatibility complex (MHC) molecules as universal adjuvants for vaccines against neoplastic disease, infection and autoimmune disease

• 收藏
• 分享

专利权人:

Moriya Tsuji

发明人:

Moriya Tsuji

申请号：

US11412149

公开号：

US09155789B2

申请日:

2006.04.25

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The present invention is directed to the discovery that allogenic or syngenic adjuvant stimulation can cause local inflammation which increases the antigen presentation capability of cells in the vicinity of adjuvant stimulation. By discovering this phenomenon, the present invention provides a novel method for augmenting the immunogencity of an antigen by conjointly administering an allogenic or syngenic MHC molecule (as a universal adjuvant) to trigger a local inflammatory reaction to enhance antigen presentation at the site of delivery.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/