作為γ分泌酶調節劑的新穎的經取代的吡啶並-哌嗪酮衍生物

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专利权人:

JANSSEN PHARMACEUTICA NV

发明人:

BISCHOFF, FRANOIS, PAUL,VELTER, ADRIANA, INGRID,ROMBOUTS, FREDERIK, JAN, RITA,DE CLEYN, MICHEL, ANNA, JOZEF,VAN BRANDT, SVEN, FRANCISCUS, ANNA,GIJSEN, HENRICUS, JACOBUS, MARIA,ZAVATTARO, CHIARA,VAN DE

申请号：

HK16100319.6

公开号：

HK1212346A

申请日:

2016.01.13

申请国别(地区):

HK

年份:

2016

代理人:

摘要：

The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R1, R2, R3, R4, R5, L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/