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Aqueous coacervate compositions suitable for making powders and water-soluble formulations of biologically-active agents
专利权人:
发明人:
申请号:
EP11174030.4
公开号:
EP2407156A3
申请日:
2011.07.14
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
This invention relates to an aqueous gel-free two-phase coacervate composition comprising a coacervate phase and an equilibrium water phase, comprising a mixture of:(a) a poorly water-soluble bio-active agent,(b) a tensio-active system with a HLB from 8 to 18 and consisting of non-ionic tensio-active agents,(c) one or more water-soluble carriers for said poorly water-soluble bio-active agent, said carriers being selected from the group consisting of polyols, and(d) water.Such coacervate compositions may be dried into solid dosage forms from which rapid release of the bio-active agent can be obtained.
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