Apparatuses and methods for medication administration via a body cavity. In one aspect, a medication administration device includes: a tip portion having a plurality of holes and a balloon defining a balloon cavity. When the balloon is deflated the tip portion can be inserted into a body cavity, such as the rectum, to allow medication delivery through the holes in the tip portion. When inflated, the balloon can prevent the tip portion from being withdrawn from the body cavity and/or hold dispersed medication within the body cavity. The device further includes a port portion that has a first port and a second port, and an elongated tubular portion that is coupled between the tip portion and the port portion. The tubular portion has a first lumen connecting the first port to the plurality of holes in the tip portion, and a second lumen connecting the second port to the balloon cavity.
