This disclosure relates to a device and method for disinfecting CPAP components using a chemically reactive substrate. Specifically, the device and method are used to disinfect CPAP components (or, CPAP equipment), including the various parts of a CPAP system, such as hoses, masks, pillows, couplings, humidifiers, etc., that require frequent cleaning and disinfecting. An exemplary device includes, among other things, a chamber, an ultraviolet (UV) light configured to emit UV light within the chamber, and a substrate chemically reactive to the UV light. Exposing the substrate to UV light releases free radicals which are configured to destroy bacteria, mold, and fungus, as well as eliminate odor. The free radicals may be circulated within the chamber and consequently within the CPAP components that are placed within the chamber to provide a thorough disinfection.