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Pyripyropene derivative having ACAT2 inhibitory activity
专利权人:
学校法人北里研究所
发明人:
供田 洋,長光 亨,大村 智
申请号:
JP2009547119
公开号:
JP5479110B2
申请日:
2008.12.17
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention is a compound having the general formula (I), (II), or (III) or a pharmacologically acceptable salt, solvate, or hydrate thereof, and a pharmaceutical composition containing such a compound, or its pharmacologically acceptable ester, or other pharmacologically acceptable derivative thereof as an active ingredient. The compound has an excellent ACAT 2-inihibiting activity by a mechanism different from that of a statin drug and is useful as a therapeutic or prophylactic agent for obesity, adiposis, hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, and arteriosclerosis, as well as obesity-derived hyperlipidemia, hypercholesterolemia, disorder of lipid metabolism, arteriosclerosis, and hypertension.
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