The present invention is directed to compositions incorporating purified herbal ingredients for the treatment of conditions such as hypercholesterolemia, hyperlipidemia, elevated triglycerides, syndrome X (metabolic syndrome), hyperglycemia, diabetes, cardiovascular disease and the like as well as disorders of lipid metabolism with failed response to standard therapies (for example statins) or any other disease or condition associated with lipids and lipid metabolism, as well as methods for their use. The compositions incorporating purified herbal ingredients can incorporate combinations of berberine and pantethine, alone or with one or more of chromium polynicotinate or chromium picolinate, biotin, curcumin and/or bioperin.
